Inline purification in continuous flow synthesis – opportunities and challenges

• Jorge García-Lacuna and
• Marcus Baumann

Beilstein J. Org. Chem. 2022, 18, 1720–1740, doi:10.3762/bjoc.18.182

• exploited to achieve effective and reliable flow processes. This perspective article summarizes recent applications of different inline purification techniques such as chromatography, extractions, and crystallization from academic and industrial laboratories. A discussion of the advantages and drawbacks of

• chemistry tools developed in academia. Keywords: flow synthesis; inline purification; process development; reaction telescoping; scale-up; Introduction Continuous flow chemistry is a mature and widely applied platform technology that exploits intrinsic advantages over batch processing such as better heat

• process. One question which is thereby of great importance is whether inline purification is required to improve the overall process. This is an important question as the removal of impurities and spent reagents typically facilitates subsequent chemical reactions in a telescoped multistep sequence. In

Coupling biocatalysis with high-energy flow reactions for the synthesis of carbamates and β-amino acid derivatives

• Alexander Leslie,
• Thomas S. Moody,
• Megan Smyth,
• Scott Wharry and
• Marcus Baumann

Beilstein J. Org. Chem. 2021, 17, 379–384, doi:10.3762/bjoc.17.33

• unstable or harmful intermediates [10][11][12][13]. Importantly, recent applications have extended from telescoping chemical transformations to also integrate bioassays [14], inline purification [15] and formulation stages [16]. This development is accompanied by exploiting biocatalyzed transformations